Biochemical properties of the NADPH oxidase in neutrophils
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چکیده
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Prostasomes inhibit the NADPH oxidase activity of human neutrophils.
Prostasomes are particular lipid vesicles secreted by the prostate in human semen and involved in several physiological functions such as the improvement of sperm motility or immunomodulation. We have previously shown that they reduced the overall reactive oxygen species (ROS) production of seminal polymorphonuclear neutrophils (PMN). The present study was conducted to define the mechanism by w...
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In the chain of events by which chemotactic peptides stimulate NADPH oxidase-catalyzed superoxide formation in human neutrophils, the involvements of a pertussis toxin-sensitive guanine nucleotide-binding protein (N-protein), mobilization of intracellular calcium and protein kinase C stimulation have been proposed. Superoxide formation was studied in membranes from human neutrophils; NADPH oxid...
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To combat bacterial infection, phagocytes generate superoxide (O2-) and other microbicidal oxygen radicals. NADPH oxidase, the enzyme responsible for O2- synthesis, is deficient in chronic granulomatous disease (CGD) patients. Although O2- generation is accompanied by a large burst of metabolic acid production, intracellular pH (pHi) remains near neutrality due to the concomitant stimulation of...
متن کاملNeutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly.
Bacterial LPS is a pluripotent agonist for PMNs. Although it does not activate the NADPH-dependent oxidase directly, LPS renders PMNs more responsive to other stimuli, a phenomenon known as "priming." Since the mechanism of LPS-dependent priming is incompletely understood, we investigated its effects on assembly and activation of the NADPH oxidase. LPS pretreatment increased superoxide (O2-) ge...
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P-21 activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils Pak regulates phagocyte NADPH oxidase Kendra D. Martyn, Moon-Ju Kim, Mark T. Quinn, Mary C. Dinauer and Ulla G. Knaus These authors contributed equally to this work Dr. Martyn and Dr. Kim performed research Dr. Quinn and Dr. Dinauer contributions are essential reagents and manuscript revision Dr. Knaus designed ...
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ژورنال
عنوان ژورنال: Ensho
سال: 1984
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.4.4_413